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14^th Congress on Alternatives to Animal Testing – Linz 2008
& 11^th Annual Meeting of MEGAT – Middle European Society for Alternative Methods to Animal Testing

• Fabrication and validation of corneal holders for porcine corneal opacity and permeability assay

• Allergenicity testing using plasmacytoid dendritic cells

• Irritation screening of vaginal-care products using EpiVaginal, a human vaginal-ectocervical tissue model

• Alternative in vitro method for detection of Pertussis Toxin in vaccines to replace the mandatory animal test

• Hungarian consensus platform on alternatives – here we go!

• Use of skin derived bovine dendritic cells to discriminate between potential haptens and irritants

Awarded with the zet Poster Award Linz 2007

• Comparison of human patch test and 3D human skin model results with classification of chemicals based on rabbit Draize test

• In vitro testing of the biocompatibility of degradable magnesium alloys for use in biomedical technology

• In vitro three dimensional trachea model

• Bio-analytic silicon chips for the detection of developmental-neurotoxic effects of chemicals and drugs in the context of the European REACH program

• Development of a screening assay for teratogenicity: combination of DarT with a mammalian metabolic activation system

• Toxicity of TBTC and Arsenic on adult and fetal blood progenitors

• Toxicological investigation of nanoparticles – effects on human cells

• Possibility to assess the harmfulness of minerals using cell culture

• In tube evaluation of the effect of cobalt, nickel and albendazol upon rumen fermentation

• HuIFN-Alpha N3 and PoIFN-Beta affect the replication of Avian Influenza (H5N2) virus in the embryonated chicken egg

• Cell-growth promoting fractions originated from calf blood clot

• Effects of a decoction of Nigella sativa, Cryptolepis buchananii and Smilax glabra on human hepatoma HepG2 cell integrity

• Bounded animal use through in vivo body fat screening with the laboratory CT LaTheta™

• Best search practice for animal alternatives – the ECVAM guide for untrained database users

• Partition and diffusion – the experimental basis for in silico modeling of skin absorption

• The use of a human in vitro airway epithelium tissue model (EpiAirway) for metabolism, toxicity screening and drug delivery applications

Awarded with the Bo Holmstedt Memorial Fund Poster Award

• Ecotoxicological hazard of ZnO, TiO2 and CuO (nano)powders: effects on bacteria, crustaceans and protozoa

Awarded with the zet Poster Award Linz 2007

• In vitro toxicity of polyethyleneimine nanoparticles on human distal lung cells in mono- and co-culture

• Determination of skin phototoxicity properties of different compounds using epidermal skin test 1000 (EST-1000)

• Online monitoring of suspension cells in the focus of in vitro immunotoxicity-studies

• InterNICHE Humane Education Award: assessing the international impact

• Expanded applicability domain for assessing ocular irritation using EpiOcular human cornel tissue model

• Genotoxicity screening using the EpiDerm human 3D model skin specific micronucleus assay

• Long term reproducibility of in vitro reconstructed skin models for regulatory testing purposes – Evidence of good tissue culture practice

• Effect of ZnO, TiO2 and CuO particle size on the growth of Saccharomyces cerevisiae

• In vitro assessment of cytotoxic and membrane toxic potential of dental materials

• Educational studies establish the efficacy of humane teaching methods in veterinary education

• Modular glass chip system for the acquisition of the electric activity and physiological parameters of differentiated stem cells

• Chorioallantoic membrane model system – different application methods for test substances

• Next of Kin: the use of primates in experiments in the EU

• Differentiated ARPE-19 can serve an in vitro model for the study of light damage to the eye

• Outreach, alternatives awareness and replacement in Russia

• Ethically sourced animal cadavers and tissue: considerations for education and training

• From Policy to Practice: illustrating the viability of full replacement

• Development of a physiological three-dimensional intestinal test system

• Smart in vitro test sequence for 'hepato-profiling' of potential new drugs

• In silico model of skin penetration based on experimentally determined input parameters

• Alternatives changing the face of education in India

• Ethical justification concerning the application under article 8 paragraph 1 of the German animal welfare act (TierSchG) after including animal welfare in the constitution

• Alternatives to the Use of Fetal Bovine Serum: Platelet Lysates as Serum Replacement in Cell and Tissue Culture

• H4IIE hepatoma cells exposed to anisoosmotic media are an alternative to animal testing studying osmotically regulated hepatic gene expression

• A vascularised liver cell module as an alternative to animal experiments

• Cultured meat; advantages of manufacturing meat products through “tissue-engineering” technology

• Gene expression profiling in dendritic cells to predict skin sensitization

• A new approach to study hypoxia in vitro

• Enlargement of the database of the validated embryonic stem cell test (EST): testing of eight substances

• Cryopreserved human whole blood (-80°C): development and optimisation of a stable monocyte source for alternative pyrogen tests (Monocyte activation tests)

• Establishment of a three-dimensional cell culture system of the canine endometrium

• Comparison of percutaneous permeation with epidermal lipid composition and histological parameters in four different species

• A cell culture model for the detection of chemical or physical agents with potential pro- or antioxidative properties using 8-hydroxy-2’-deoxyguanosine in cellular DNA as toxicological endpoint

• Dramatic increase in numbers of transgenic mice – we must take action now!

• Use of an alternative test battery to predict ocular irritancy of agrochemicals

• In vitro and in vivo screening of azole fungicides for antiandrogenic effects

• How do we assess the value of fundamental research using animals?

• Towards the validation of Caco-2 cell line as model of intestinal absorption

Awarded with the Four Pows Poster Award Linz 2007

• Follicular penetration – in vitro testing of rigid and flexible liposomes

• Development and pre-validation of an in vitro method for the prediction of drug-drug interactions and intestinal absorptions of P-glycoprotein substrates using cell monolayers

• Establishment and pre-validation of a pulmonary in vitro model for transport and toxicity studies

• New bioethical forms of educational process in universities of Armenia

• Isolation and characterization of bovine intestinal epithelial cells

• Towards an in vitro test system for developmental neurotoxicity: a new test method using mouse embryonic stem cells

• Construction and functional testing of a three-dimensional cornea equivalent using primary canine corneal cells

• Prevalidation of the MELN assay, a reporter cell line to screen for estrogenic activity